PHKB Polyclonal Antibody

Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by PHKB (phosphorylase kinase regulatory subunit beta), which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in PHKB cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.

The PHKB Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced using high-quality polyclonal antibodies that have been purified and validated to ensure optimal performance. The PHKB Polyclonal Antibody is specifically designed to target the PHKB protein, which is involved in the regulation of glycogen metabolism. This antibody is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence. The PHKB Polyclonal Antibody is a reliable and effective tool for researchers seeking to investigate the role of PHKB in various biological processes. With its high specificity and sensitivity, this antibody is an essential tool for any researcher working in the field of glycogen metabolism.