P-glycoprotein 1 Polyclonal Antibody

The membrane-associated protein encoded by B1 (ATP binding cassette subfamily B member 1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by B1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

The P-glycoprotein 1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of P-glycoprotein 1 (P-gp) in various biological samples. This antibody is produced through a rigorous process, ensuring its high affinity and sensitivity towards P-gp.

P-gp, also known as multidrug resistance protein 1 (MDR1), is a transmembrane protein that plays a crucial role in the efflux of a wide range of drugs and xenobiotics from cells. It is widely expressed in various tissues, including the liver, kidney, intestine, and blood-brain barrier. The overexpression of P-gp has been associated with multidrug resistance in cancer cells, making it an important target for therapeutic interventions.

The P-glycoprotein 1 Polyclonal Antibody has been extensively validated for its specificity and reliability in various applications, including Western blotting, immunohistochemistry, and flow cytometry. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and precise detection of P-gp.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for additional reagents or preparations. The P-glycoprotein 1 Polyclonal Antibody is compatible with a wide range of sample types, including cell lysates, tissue homogenates, and biological fluids.

With its exceptional performance characteristics, the P-glycoprotein 1 Polyclonal Antibody is an indispensable tool for researchers and scientists involved in drug discovery, pharmacology, and cancer research. Its high specificity, sensitivity, and ease of use make it an ideal choice for studying the expression and function of P-gp in various biological systems.

Order your P-glycoprotein 1 Polyclonal Antibody today and unlock new insights into the role of P-gp in drug resistance and therapeutic strategies.