Peroxin 5 Polyclonal Antibody

The product of PEX5 (peroxisomal biogenesis factor 5) binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in PEX5 are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.

The Peroxin 5 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Peroxin 5 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Peroxin 5 protein. The antibody has been purified using Protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Peroxin 5 Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize Peroxin 5 protein in various human and animal tissues, including liver, kidney, and brain. The antibody has also been shown to be highly sensitive, with a detection limit of 0.1 ng/mL.

This antibody is an essential tool for researchers studying the role of Peroxin 5 protein in various cellular processes, including peroxisome biogenesis and lipid metabolism. It is also useful for diagnostic applications, such as the detection of Peroxin 5 protein in patient samples for the diagnosis of peroxisomal disorders.

In summary, the Peroxin 5 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of Peroxin 5 protein in various biological samples. Its extensive validation and broad range of applications make it an essential tool for researchers and clinicians alike.