PEPCK-C Polyclonal Antibody

PCK1 is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.

The PEPCK-C Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Phosphoenolpyruvate Carboxykinase (PEPCK-C) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PEPCK-C protein. The PEPCK-C Polyclonal Antibody has been extensively validated for its specificity and sensitivity in Western blotting, immunohistochemistry, and immunofluorescence assays. It recognizes PEPCK-C protein from various species, including human, mouse, rat, and bovine. This antibody is an essential tool for researchers studying the regulation of gluconeogenesis, glucose metabolism, and energy homeostasis. It is supplied as a purified IgG fraction, which can be used at a recommended dilution of 1:1000 for Western blotting and 1:200 for immunohistochemistry and immunofluorescence assays. The PEPCK-C Polyclonal Antibody is a reliable and high-quality reagent that can provide accurate and reproducible results in various applications.