PEBP2Beta Polyclonal Antibody

Core-binding factor beta subunit encoded by CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e. G. RUNX1) and osteogenesis (e. G. RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for CBFB.

The PEBP2Beta Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of PEBP2Beta protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, ensuring its exceptional sensitivity and specificity.

The PEBP2Beta Polyclonal Antibody exhibits a high affinity towards the PEBP2Beta protein, enabling accurate and precise detection even at low concentrations. It has been extensively validated through rigorous testing procedures, guaranteeing its consistent performance and reproducibility.

This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It provides robust and clear signals, facilitating the identification and quantification of PEBP2Beta protein in diverse experimental settings.

Furthermore, the PEBP2Beta Polyclonal Antibody is manufactured under strict quality control standards, ensuring its reliability and consistency. It is produced using state-of-the-art techniques and undergoes thorough purification processes to eliminate any potential contaminants, guaranteeing optimal performance and minimal background noise.

In summary, the PEBP2Beta Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of PEBP2Beta protein. Its exceptional sensitivity, versatility, and stringent quality control measures make it an ideal choice for researchers and scientists working in various fields of life sciences.