PCAF (Acetyl Lys428) Polyclonal Antibody

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. lysine acetyltransferase 2B associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that lysine acetyltransferase 2B plays a direct role in transcriptional regulation.

The PCAF (Acetyl Lys428) Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of PCAF protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated lysine 428 of the human PCAF protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The PCAF (Acetyl Lys428) Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It recognizes a single band of the expected size in Western blot analysis of PCAF protein from various cell lines and tissues. The antibody also shows minimal cross-reactivity with other acetylated lysine residues or non-acetylated PCAF protein.

This antibody is an essential tool for researchers studying the role of PCAF protein in various cellular processes, including transcriptional regulation, DNA repair, and cell cycle control. It can also be used for diagnostic purposes in clinical settings, such as the detection of PCAF protein in cancer tissues.

In summary, the PCAF (Acetyl Lys428) Polyclonal Antibody is a reliable and high-quality reagent that provides accurate and reproducible results in various applications. Its specificity and sensitivity make it an ideal choice for researchers and clinicians working in the field of molecular biology and medicine.