Pax-5 Polyclonal Antibody

PAX5 encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

The Pax-5 Polyclonal Antibody is a highly reliable and efficient tool for the detection and analysis of Pax-5 protein expression in various biological samples. This antibody is produced using advanced techniques, ensuring exceptional specificity and sensitivity.

The Pax-5 Polyclonal Antibody exhibits a strong affinity towards the Pax-5 protein, enabling accurate identification and quantification of this transcription factor. It has been extensively validated in a wide range of applications, including immunohistochemistry, western blotting, and flow cytometry.

With its exceptional performance, this antibody allows for precise and reliable detection of Pax-5 protein expression in both normal and diseased tissues. Its high sensitivity ensures accurate results even with low abundance samples, making it an ideal choice for research and diagnostic purposes.

The Pax-5 Polyclonal Antibody is manufactured under strict quality control measures, ensuring batch-to-batch consistency and reproducibility. It is supplied in a convenient format, ready for immediate use in various experimental settings.

Choose the Pax-5 Polyclonal Antibody for its exceptional performance, reliability, and versatility. It is an indispensable tool for researchers and clinicians alike, facilitating the study and understanding of Pax-5 protein expression in diverse biological contexts.