Patched Polyclonal Antibody

PTCH1 (patched 1) encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of PTCH1 have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

PBK Polyclonal Antibody is a highly specific and sensitive antibody that is designed to detect the expression of PBK protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PBK protein. The resulting polyclonal antibody is purified using protein A affinity chromatography and is validated for its specificity and sensitivity by various immunoassays.

PBK (PDZ-binding kinase) is a serine/threonine kinase that plays a crucial role in cell proliferation, survival, and migration. It is overexpressed in various types of cancer, including breast, lung, and prostate cancer, and is considered as a potential therapeutic target. The PBK Polyclonal Antibody can be used for various applications, including Western blotting, immunohistochemistry, and immunofluorescence, to study the expression and localization of PBK protein in different tissues and cell lines.

The PBK Polyclonal Antibody is supplied as a liquid in phosphate-buffered saline (PBS) containing 0.02% sodium azide as a preservative. It is available in different sizes and formats to meet the specific needs of researchers. This antibody is highly recommended for researchers who are interested in studying the role of PBK protein in cancer and other diseases. With its high specificity and sensitivity, the PBK Polyclonal Antibody is a valuable tool for biomedical research.