PAF-R Polyclonal Antibody

PTAFR (platelet activating factor receptor) encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

The PAF-R Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of Platelet-Activating Factor Receptor (PAF-R) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the PAF-R protein sequence.

The PAF-R Polyclonal Antibody exhibits exceptional affinity and selectivity towards PAF-R, enabling accurate and reliable detection of this protein in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its specificity and sensitivity, ensuring consistent and reproducible results.

With its superior performance characteristics, the PAF-R Polyclonal Antibody offers researchers a valuable tool for investigating the role of PAF-R in various physiological and pathological processes. Its application in research areas such as inflammation, immune response, and cardiovascular diseases holds great potential for advancing our understanding of PAF-R-mediated signaling pathways.

The PAF-R Polyclonal Antibody is provided as a liquid formulation, ready for immediate use. It is supplied in a convenient size and concentration, ensuring cost-effective and efficient experimental procedures. Each batch of the antibody undergoes rigorous quality control measures to guarantee its performance and reliability.

Choose the PAF-R Polyclonal Antibody for its exceptional specificity, sensitivity, and reliability, and unlock new insights into the intricate mechanisms governed by PAF-R in biological systems.