p63 Polyclonal Antibody

TP63 (tumor protein p63) encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain.

Alternative splicing of TP63 and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging.

Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in TP63 are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.

The p63 Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced using high-quality materials and advanced techniques to ensure optimal performance and reliability. It is designed to detect the p63 protein, which is a member of the p53 family of transcription factors and plays a crucial role in the regulation of cell proliferation and differentiation. The p63 Polyclonal Antibody is suitable for use in various techniques, including Western blotting, immunohistochemistry, and immunofluorescence.

It has been extensively validated for its specificity and sensitivity, making it an ideal tool for researchers studying the function and regulation of the p63 protein. With its superior performance and reliability, the p63 Polyclonal Antibody is an essential tool for any researcher working in the field of cell biology and molecular biology.