p53 (Di Methyl Lys370) Polyclonal Antibody

TP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains.Tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of TP53 and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53 (Di Methyl Lys370) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein in various biological samples. This antibody is produced using advanced techniques and is rigorously tested to ensure its high quality and reliability.

The p53 protein plays a crucial role in regulating cell cycle progression and preventing the formation of tumors. The Di Methyl Lys370 modification of p53 has been shown to be involved in the regulation of gene expression and DNA repair processes. Therefore, the p53 (Di Methyl Lys370) Polyclonal Antibody is an invaluable tool for researchers studying the molecular mechanisms underlying cancer development and progression.

This antibody exhibits excellent specificity towards p53 protein, with minimal cross-reactivity to other proteins. It has been validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. The high sensitivity of this antibody allows for the detection of low levels of p53 protein, making it suitable for use in both basic research and clinical diagnostics.

The p53 (Di Methyl Lys370) Polyclonal Antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming preparation steps. The antibody is also available in different sizes to accommodate various experimental needs.

In summary, the p53 (Di Methyl Lys370) Polyclonal Antibody is a reliable and specific tool for the detection and analysis of p53 protein. Its high sensitivity and excellent performance in various applications make it an essential reagent for researchers and clinicians working in the field of cancer biology and diagnostics.