p53 (Acetyl Lys382) Polyclonal Antibody

TP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains.Tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of TP53 and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53 (Acetyl Lys382) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein acetylated at Lysine 382. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Acetylation of p53 at Lysine 382 has been shown to enhance its transcriptional activity and stability, thereby influencing its tumor suppressor function. Therefore, the detection and quantification of p53 acetylated at Lysine 382 is of great importance in cancer research and drug development.

This polyclonal antibody is derived from a host animal immunized with a synthetic peptide corresponding to the acetylated Lysine 382 region of the p53 protein. It exhibits high affinity and specificity towards the acetylated form of p53, enabling accurate and reliable detection in various experimental applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The p53 (Acetyl Lys382) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimizing waste. Each batch of antibody undergoes stringent quality control testing to guarantee consistent performance and lot-to-lot reproducibility.

In summary, the p53 (Acetyl Lys382) Polyclonal Antibody is a valuable tool for researchers studying the role of p53 acetylation in cancer biology. Its high specificity, sensitivity, and reliability make it an essential component of any laboratory involved in p53-related research.