p53 (Acetyl Lys373) Polyclonal Antibody

TP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains.Tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of TP53 and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53 (Acetyl Lys373) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein acetylated at Lys373 residue. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Acetylation of the Lys373 residue has been shown to enhance the transcriptional activity of p53, leading to increased expression of downstream target genes involved in cell cycle arrest and apoptosis. Therefore, the detection and quantification of acetylated p53 at Lys373 is of great importance in understanding the functional role of p53 in various cellular processes.

This polyclonal antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of acetylated p53 at Lys373 in a wide range of sample types, including cell lysates and tissue extracts.

The p53 (Acetyl Lys373) Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate application. It is provided in a convenient size, ensuring cost-effectiveness and minimizing waste. The antibody is manufactured under strict quality control standards, guaranteeing consistent and reproducible results.

In summary, the p53 (Acetyl Lys373) Polyclonal Antibody is a valuable tool for researchers studying the functional role of p53 protein acetylation. Its high specificity, sensitivity, and versatility make it an ideal choice for various applications in molecular biology, cancer research, and drug discovery.