p53 (Acetyl Lys372) Polyclonal Antibody

TP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. Tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of TP53 and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53 (Acetyl Lys372) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein acetylated at Lys372 residue. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Acetylation of p53 at Lys372 residue has been shown to enhance its transcriptional activity and stability, thereby influencing its tumor suppressor function. Therefore, the detection and quantification of p53 acetylation at Lys372 is of great importance in understanding the molecular mechanisms underlying various cellular processes and diseases, particularly cancer.

This polyclonal antibody has been extensively validated for its performance in various applications, including Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of p53 acetylation at Lys372 in a wide range of sample types, including cell lysates, tissue extracts, and formalin-fixed paraffin-embedded (FFPE) sections.

The p53 (Acetyl Lys372) Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate application. It is provided in a convenient size and format, ensuring ease of use and minimizing waste. The antibody is manufactured under strict quality control standards, guaranteeing consistent and reproducible results.

In summary, the p53 (Acetyl Lys372) Polyclonal Antibody is a valuable tool for researchers and scientists involved in studying p53 protein acetylation and its implications in various biological processes and diseases. Its high specificity, sensitivity, and versatility make it an essential component of any laboratory working in the field of molecular biology and cancer research.