p53 (Acetyl Lys370) Polyclonal Antibody

TP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. Tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in TP53 are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of TP53 and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

The p53 (Acetyl Lys370) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p53 protein acetylated at Lysine 370. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity for the target protein.

The p53 protein plays a crucial role in regulating cell cycle progression, DNA repair, and apoptosis. Acetylation of p53 at Lysine 370 has been shown to enhance its transcriptional activity and stability, leading to increased tumor suppressor function. Therefore, the detection and quantification of p53 acetylated at Lysine 370 is of great importance in cancer research and drug development.

This polyclonal antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other acetylated lysine residues, ensuring accurate and reliable results.

With its high sensitivity and specificity, the p53 (Acetyl Lys370) Polyclonal Antibody is an indispensable tool for researchers studying the role of p53 acetylation in cancer biology. Its superior performance and consistent results make it an ideal choice for both basic research and clinical applications.