p40-phox Polyclonal Antibody

The protein encoded by NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of neutrophil cytosolic factor 4 was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

The p40-phox Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of p40-phox protein in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

The p40-phox Polyclonal Antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated and proven to provide reliable and reproducible results in these assays.

With its exceptional sensitivity, this antibody allows for the detection of even low levels of p40-phox protein, making it an ideal choice for researchers working with limited sample quantities. Its high specificity ensures minimal cross-reactivity with other proteins, ensuring accurate and precise results.

The p40-phox Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering.

In summary, the p40-phox Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of p40-phox protein. Its high specificity, sensitivity, and ease of use make it an invaluable asset for researchers in the field of molecular biology and immunology.