p35 Polyclonal Antibody

Cyclin dependent kinase 5 regulatory subunit 1 encoded by CDK5R1 (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of cyclin dependent kinase 5 regulatory subunit 1 is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

The p35 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of p35 protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a region of the p35 protein. It has been extensively validated for its specificity and sensitivity in Western blotting, immunohistochemistry, and immunofluorescence applications.

The p35 Polyclonal Antibody exhibits exceptional affinity and selectivity towards the p35 protein, making it an ideal choice for researchers studying the role of p35 in various cellular processes. It recognizes both the full-length p35 protein and its cleaved fragments, allowing for comprehensive analysis of p35 expression and processing.

This antibody is supplied as a purified and lyophilized preparation, ensuring long-term stability and ease of use. It can be reconstituted in a variety of buffers, making it compatible with different experimental conditions. The p35 Polyclonal Antibody is suitable for use in both basic research and clinical applications, providing valuable insights into the function and regulation of the p35 protein.

With its exceptional specificity, sensitivity, and versatility, the p35 Polyclonal Antibody is an indispensable tool for scientists and clinicians working in the field of molecular biology and protein analysis. Its reliable performance and consistent results make it a trusted choice for a wide range of applications, enabling breakthrough discoveries and advancements in scientific knowledge.