p300 Polyclonal Antibody

EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in EP300 are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

The P300 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of P300 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human P300 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards P300 protein, making it an ideal tool for a wide range of applications in research and diagnostics.

The P300 Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples, and has been shown to detect endogenous P300 protein in a variety of cell types and tissues. The antibody is supplied as a purified IgG fraction, and has been tested for purity, specificity, and activity to ensure consistent and reliable results.

In summary, the P300 Polyclonal Antibody is a high-quality immunological reagent that offers exceptional sensitivity and specificity for the detection and quantification of P300 protein in various biological samples. Its versatility and reliability make it an essential tool for researchers and clinicians working in a wide range of fields, including cancer research, developmental biology, and neurobiology.