p27 Polyclonal Antibody

CDKN1B encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. Cyclin dependent kinase inhibitor 1B binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of cyclin dependent kinase inhibitor 1B, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in CDKN1B are associated with multiple endocrine neoplasia type IV (MEN4).

The P27 Polyclonal Antibody is a highly specific and reliable tool for various research applications. This antibody is produced by immunizing animals with a purified recombinant protein corresponding to the P27 antigen. It has been extensively validated for its specificity and sensitivity, ensuring accurate and reproducible results.

The P27 Polyclonal Antibody exhibits a strong affinity towards the P27 antigen, making it an ideal choice for detecting and quantifying P27 protein levels in various biological samples. It can be used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence, enabling researchers to study the expression and localization of P27 in different tissues and cell types.

With its high specificity and sensitivity, the P27 Polyclonal Antibody offers researchers a valuable tool for investigating the role of P27 in various biological processes. It can aid in understanding the regulation of cell cycle progression, cell proliferation, and differentiation. Additionally, this antibody can be used to explore the potential diagnostic and therapeutic applications of P27 in diseases such as cancer.

The P27 Polyclonal Antibody is supplied as a ready-to-use solution, ensuring convenience and ease of use. It is available in different sizes to accommodate various experimental needs. Each batch of antibody undergoes rigorous quality control tests to ensure consistent performance and reliability.

In summary, the P27 Polyclonal Antibody is a highly specific and reliable tool for studying the expression and function of P27 protein. Its versatility and accuracy make it an essential component in any research involving P27-related investigations.