p16 Polyclonal Antibody

CDKN2A (cyclin dependent kinase inhibitor 2A) generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. CDKN2A is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

The p16 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of p16 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

The p16 Polyclonal Antibody exhibits exceptional affinity and selectivity towards the p16 protein, making it an ideal choice for researchers and clinicians involved in cancer research and diagnostics. It has been extensively validated in a wide range of applications, including immunohistochemistry, western blotting, and flow cytometry.

With its superior performance characteristics, the p16 Polyclonal Antibody offers reliable and accurate results, enabling precise analysis of p16 protein expression levels. Its exceptional sensitivity allows for the detection of even low levels of p16, making it an invaluable tool for studying the role of p16 in various disease states.

Furthermore, the p16 Polyclonal Antibody is manufactured under strict quality control measures, ensuring consistent performance and reproducibility. It is supplied in a convenient and user-friendly format, allowing for easy handling and storage.

In summary, the p16 Polyclonal Antibody is a highly reliable and efficient tool for the detection and quantification of p16 protein expression. Its exceptional sensitivity, specificity, and consistency make it an indispensable asset for researchers and clinicians in the field of cancer research and diagnostics.