Nup88 Polyclonal Antibody

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nuclear pore complex protein Nup88 encoded by NUP88 belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms.

The NUP88 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of NUP88 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human NUP88 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards NUP88 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and immunofluorescence.

The NUP88 Polyclonal Antibody is manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure its purity, specificity, and consistency. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different research applications.

The NUP88 protein is a component of the nuclear pore complex (NPC) that regulates the transport of macromolecules between the nucleus and cytoplasm. Aberrant expression of NUP88 has been implicated in various diseases, including cancer. Therefore, the NUP88 Polyclonal Antibody is a valuable tool for researchers studying the role of NUP88 in disease pathogenesis and for the development of novel therapeutic strategies.

In summary, the NUP88 Polyclonal Antibody is a high-quality immunological reagent that offers exceptional sensitivity and specificity for the detection and quantification of NUP88 protein. Its superior performance and reliability make it an essential tool for researchers in the fields of cell biology, molecular biology, and biomedical research.