Nrf2 (Acetyl Lys599) Polyclonal Antibody

NFE2L2 encodes a transcription factor (nuclear factor, erythroid 2 like 2) which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for NFE2L2.

The Nrf2 (Acetyl Lys599) Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Nrf2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated Lys599 region of human Nrf2 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Nrf2 protein is a transcription factor that plays a crucial role in the regulation of cellular defense mechanisms against oxidative stress and inflammation. The acetylation of Lys599 residue in Nrf2 protein has been shown to enhance its transcriptional activity and promote the expression of antioxidant and detoxification genes. Therefore, the Nrf2 (Acetyl Lys599) Polyclonal Antibody is an essential tool for researchers studying the molecular mechanisms underlying oxidative stress and related diseases.

The Nrf2 (Acetyl Lys599) Polyclonal Antibody has been validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. The antibody exhibits high specificity and sensitivity, with minimal cross-reactivity to other proteins. It has been tested in various cell lines and tissues, including human, mouse, and rat, and has shown excellent performance in detecting endogenous Nrf2 protein.

In summary, the Nrf2 (Acetyl Lys599) Polyclonal Antibody is a reliable and high-quality antibody that is ideal for the detection of Nrf2 protein in various biological samples. Its high specificity and sensitivity make it an essential tool for researchers studying oxidative stress and related diseases.