NFKappaB-p65 (Acetyl Lys221) Polyclonal Antibody

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for RELA.

The NFKappaB-p65 (Acetyl Lys221) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of NFKappaB-p65 protein in various biological samples. This antibody has been extensively validated and exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The NFKappaB-p65 (Acetyl Lys221) Polyclonal Antibody is produced using state-of-the-art techniques, ensuring high purity and batch-to-batch consistency. It is derived from a host animal that has been immunized with a synthetic peptide corresponding to the acetylated lysine 221 region of the NFKappaB-p65 protein. This antibody specifically recognizes the acetylated form of NFKappaB-p65, enabling precise detection and analysis of post-translational modifications.

With its exceptional sensitivity, this antibody allows for the detection of low-abundance NFKappaB-p65 protein levels, making it an invaluable tool for researchers studying the intricate regulatory mechanisms involving NFKappaB-p65. Its high specificity ensures minimal cross-reactivity with other proteins, providing reliable and accurate results.

The NFKappaB-p65 (Acetyl Lys221) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. Each batch is accompanied by a detailed datasheet, providing comprehensive information on the antibody's performance characteristics and recommended experimental conditions.

In summary, the NFKappaB-p65 (Acetyl Lys221) Polyclonal Antibody is a superior research tool that offers exceptional sensitivity, specificity, and reliability. Its application in various experimental techniques makes it an indispensable asset for scientists investigating the role of NFKappaB-p65 in cellular processes and disease mechanisms.