NFKappaB-p105 Polyclonal Antibody

NFKB1 encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

The NFKappaB-p105 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of NFKappaB-p105 protein in various biological samples. This antibody is produced through a rigorous process of immunization and purification, ensuring its high affinity and specificity towards the target protein.

The NFKappaB-p105 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its superior sensitivity allows for the detection of even low abundance levels of NFKappaB-p105 protein, enabling accurate and reliable results.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, eliminating the need for time-consuming reconstitution procedures.

The NFKappaB-p105 Polyclonal Antibody is compatible with various sample types, including cell lysates, tissue extracts, and purified proteins. Its versatility and robustness make it an ideal choice for researchers and scientists working in the fields of immunology, cell biology, and molecular biology.

With its exceptional performance, high specificity, and ease of use, the NFKappaB-p105 Polyclonal Antibody is an indispensable tool for studying the role and function of NFKappaB-p105 protein in various biological processes.