NF-L Polyclonal Antibody

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

The NF-L Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of neurofilament light chain (NF-L) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human NF-L protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and is suitable for use in various applications, including Western blotting, immunohistochemistry, and ELISA.

The NF-L Polyclonal Antibody has been extensively validated for its specificity and sensitivity in detecting NF-L protein in various tissues and cell types. It has been shown to recognize both human and mouse NF-L protein with high affinity and specificity. This antibody has also been shown to be highly sensitive, with a detection limit of 0.1 ng/mL in ELISA assays.

The NF-L Polyclonal Antibody is a valuable tool for researchers studying neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. It can be used to detect changes in NF-L protein levels in biological samples, which may be indicative of disease progression or response to treatment. Additionally, this antibody can be used to study the role of NF-L protein in neuronal development and function.

Overall, the NF-L Polyclonal Antibody is a reliable and high-quality antibody that is suitable for a wide range of applications in neuroscience research. Its specificity, sensitivity, and versatility make it an essential tool for researchers studying the role of NF-L protein in health and disease.