1 1

BT Lab

BT-AP05959

NF-E4 (Acetyl Lys43) Polyclonal Antibody

NF-E4 (Acetyl Lys43) Polyclonal Antibody

$275.00 USD
$275.00 USD
Sale Sold out
Shipping calculated at checkout.
Size
Host
Ab type

The erythroid-specific protein encoded by NFE4, and the ubiquitous transcription factor CP2, form the stage selector protein(SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG(CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform(22 kDa) acts as an activator, the short isoform(14 kDa) has been shown to repress gamma-globin gene expression. NFE4 is located in an intron of the FBXL13 gene on the opposite strand.

The NF-E4 (Acetyl Lys43) Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of NF-E4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated lysine 43 of the NF-E4 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The NF-E4 protein is a transcription factor that plays a crucial role in the regulation of gene expression during erythropoiesis. The acetylation of lysine 43 of the NF-E4 protein has been shown to enhance its transcriptional activity, making it an important target for research in the field of hematopoiesis. The NF-E4 (Acetyl Lys43) Polyclonal Antibody has been validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

This antibody has been extensively characterized for its specificity and sensitivity, ensuring reliable and reproducible results. It has been shown to recognize the acetylated lysine 43 of the NF-E4 protein with high affinity and specificity, while exhibiting minimal cross-reactivity with other proteins. The NF-E4 (Acetyl Lys43) Polyclonal Antibody is an essential tool for researchers studying the role of NF-E4 in erythropoiesis and other biological processes.
View full details