Neurofibromin Polyclonal Antibody

NF1 product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

The Neurofibromin Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of neurofibromin protein expression. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

Neurofibromin, a tumor suppressor protein, plays a crucial role in the regulation of cell growth and differentiation. Dysregulation or loss of neurofibromin function has been implicated in the development of various diseases, including neurofibromatosis type 1 (NF1) and certain types of cancer.

The Neurofibromin Polyclonal Antibody exhibits exceptional affinity and selectivity towards neurofibromin, enabling accurate and reliable detection in various sample types, including tissue lysates and cell extracts. Its high sensitivity allows for the detection of low-abundance neurofibromin protein levels, facilitating precise quantification and analysis.

This antibody is validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It is compatible with a wide range of species, making it suitable for use in diverse research settings.

With its exceptional performance characteristics and reliable results, the Neurofibromin Polyclonal Antibody is an indispensable tool for researchers studying neurofibromin biology and its implications in disease pathogenesis.