Nectin 4 Polyclonal Antibody

NECTIN4 (nectin cell adhesion molecule 4) encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in NECTIN4 are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

The Nectin 4 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Nectin 4 protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

The Nectin 4 Polyclonal Antibody exhibits exceptional affinity and specificity towards Nectin 4, a cell adhesion molecule that plays a crucial role in cell-cell interactions and tissue organization. It is widely expressed in various tissues, including epithelial cells of the respiratory and reproductive tracts, as well as in certain cancer cells.

This antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It demonstrates excellent performance in detecting Nectin 4 protein in both normal and diseased tissues, making it an invaluable tool for researchers studying the role of Nectin 4 in various physiological and pathological processes.

The Nectin 4 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimal wastage. The antibody is also compatible with a wide range of secondary detection systems, allowing for flexibility in experimental design.

With its exceptional sensitivity, specificity, and versatility, the Nectin 4 Polyclonal Antibody is an indispensable tool for researchers and scientists working in the fields of cell biology, cancer research, and immunology. Its reliable performance and consistent results make it an ideal choice for a wide range of applications, enabling groundbreaking discoveries and advancements in the understanding of Nectin 4 biology.