NDUFS3 Polyclonal Antibody

NDUFS3 encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH: ubiquinone oxidoreductase  (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.

The NDUFS3 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of NDUFS3 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human NDUFS3 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The NDUFS3 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes a single band of approximately 30 kDa in Western blot analysis of human, mouse, and rat tissue lysates. In addition, it shows strong staining of mitochondria in immunohistochemistry and immunofluorescence assays.

This antibody is an essential tool for researchers studying mitochondrial function and dysfunction, as NDUFS3 is a critical subunit of complex I of the mitochondrial respiratory chain. It is involved in the transfer of electrons from NADH to ubiquinone and plays a crucial role in ATP production. The NDUFS3 Polyclonal Antibody can be used to investigate the expression and localization of NDUFS3 in various tissues and cell types, as well as to study the effects of genetic and environmental factors on its expression and function.

In summary, the NDUFS3 Polyclonal Antibody is a reliable and high-quality reagent that can be used for a wide range of applications in mitochondrial research. Its specificity, sensitivity, and versatility make it an indispensable tool for scientists investigating the role of NDUFS3 in mitochondrial function and disease.