MUM1 Polyclonal Antibody

DNA double-strand breaks (DSBs) are potentially hazardous lesions that can be induced by ionizing radiation (IR), radiomimetic chemicals, or DNA replication inhibitors. Melanoma associated antigen (mutated) 1 (MUM1, EXPAND1) is a PWWP-domain containing chromatin binding protein involved in maintaining chromatin architecture of interphase chromosomes. In response to DNA damage, EXPAND1/MUM1 accumulates at sites of DNA double strand breaks through direct interaction with DNA repair factor 53BP1. Accumulation of EXPAND1/MUM1 at damaged DNA sites is thought to modify the structure of the chromatin and allow access to other DNA repair factors. 53BP1 activates the checkpoint kinase ATM and promotes DNA double strand break repair via nonhomologous end joining (NHEJ) repair pathway.

The MUM1 Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and analysis of MUM1 protein expression. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The MUM1 Polyclonal Antibody exhibits exceptional affinity and selectivity towards the MUM1 protein, enabling accurate and precise identification of MUM1 expression in various biological samples. It is suitable for use in a wide range of applications, including immunohistochemistry, western blotting, and flow cytometry.

With its superior sensitivity, this antibody allows for the detection of even low levels of MUM1 protein, making it an invaluable tool for researchers and clinicians studying MUM1-related diseases and disorders. Its robust performance and consistent results ensure reproducibility and reliability in experimental settings.

The MUM1 Polyclonal Antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a liquid formulation, eliminating the need for reconstitution and minimizing the risk of sample contamination.

We take pride in the quality and performance of our products, and the MUM1 Polyclonal Antibody is no exception. It has undergone extensive testing and validation to ensure its specificity, sensitivity, and consistency. Each batch is accompanied by a detailed datasheet, providing comprehensive information on its recommended usage, storage conditions, and handling instructions.

Choose the MUM1 Polyclonal Antibody for reliable and accurate detection of MUM1 protein expression. Experience the confidence and precision that comes with using a high-quality immunological tool designed to meet the demands of modern research and diagnostics.