MRG15 Polyclonal Antibody

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

The MRG15 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of MRG15 protein expression in various biological samples. This antibody is produced using state-of-the-art technology and has been rigorously validated to ensure optimal performance and accuracy.

The MRG15 Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling researchers to confidently investigate the role of MRG15 in various cellular processes and pathways. It is suitable for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody is manufactured using high-quality materials and undergoes stringent quality control measures to guarantee batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, allowing for easy and convenient handling.

The MRG15 Polyclonal Antibody offers outstanding performance, delivering clear and reliable results with minimal background noise. Its superior affinity and selectivity make it an indispensable tool for researchers in the fields of molecular biology, biochemistry, and cell biology.

With its exceptional quality and reliability, the MRG15 Polyclonal Antibody is an invaluable asset for any laboratory seeking to explore the intricate mechanisms underlying MRG15 protein function.