MMP-12 Polyclonal Antibody

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, Stromelysin-3 encoded by MMP11 is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

The MMP-12 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of matrix metalloproteinase-12 (MMP-12) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human MMP-12 protein. The MMP-12 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and ELISA.

This antibody is a valuable tool for researchers studying the role of MMP-12 in various physiological and pathological processes, such as tissue remodeling, inflammation, and cancer. The MMP-12 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using protein A chromatography. This ensures high purity and specificity of the antibody, which minimizes non-specific binding and background noise in experiments.

The MMP-12 Polyclonal Antibody is available in various sizes and formats to suit different experimental needs. It is recommended to use this antibody at a dilution of 1:1000 for Western blotting and 1:200 for immunohistochemistry. The antibody has been validated for use in human, mouse, and rat samples.

In summary, the MMP-12 Polyclonal Antibody is a reliable and specific tool for the detection of MMP-12 in various biological samples. Its high sensitivity and specificity make it an ideal choice for researchers studying the role of MMP-12 in various physiological and pathological processes.