MKP-3 Polyclonal Antibody

The dual specificity phosphatase 6 encoded by DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.

The MKP-3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of mitogen-activated protein kinase phosphatase 3 (MKP-3) in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

With its polyclonal nature, this antibody exhibits a broad reactivity towards MKP-3 from different species, making it an ideal choice for researchers working with diverse experimental models. Its high affinity and specificity enable accurate and precise detection of MKP-3, facilitating in-depth investigations into its role in cellular signaling pathways.

The MKP-3 Polyclonal Antibody is manufactured under stringent quality control measures to guarantee batch-to-batch consistency and reproducibility. It has been validated for various applications, including Western blotting, immunohistochemistry, and immunofluorescence, providing researchers with versatile options for their experimental needs.

Furthermore, this antibody is supplied in a convenient and user-friendly format, ensuring ease of use and storage. Its long shelf life and stability allow for prolonged usage without compromising performance, making it a cost-effective solution for long-term research projects.

In summary, the MKP-3 Polyclonal Antibody is a reliable and efficient tool for the detection and quantification of MKP-3 in a wide range of biological samples. Its exceptional sensitivity, specificity, and versatility make it an invaluable asset for researchers aiming to unravel the intricate mechanisms of cellular signaling pathways.