MIP-1b Polyclonal Antibody

CCL4, also known as macrophage inflammatory protein 1 beta (MIP-1 beta ), is a 12 kDa beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. A CCL4 deficiency in mice promotes the development of autoantibodies, possibly as a result of compromised regulatory T cell recruitment. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. The first two N-terminal amino acids can be cleaved from human CCL4 by CD26/DPPIV. Both the full length and truncated forms exert biological activity through CCR5, and the truncated form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a co-receptor. Both forms of CCL4 block HIV-1 infection of T cells by inducing the downregulation of CCR5. Mature mouse CCL4 shares 77% and 86% amino acid sequence identity with human and rat CCL4, respectively.

The MIP-1b Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of MIP-1b protein in various biological samples. This antibody is produced through a rigorous process of immunization and purification, ensuring its high affinity and specificity towards the target protein.

The MIP-1b Polyclonal Antibody exhibits exceptional sensitivity, allowing for the detection of even low levels of MIP-1b protein. Its superior performance is attributed to its polyclonal nature, which enables recognition of multiple epitopes on the target protein, enhancing the accuracy and reliability of the results obtained.

This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISA). Its versatility allows for the analysis of MIP-1b protein in various sample types, such as cell lysates, tissue extracts, and biological fluids.

The MIP-1b Polyclonal Antibody is manufactured under strict quality control standards, ensuring batch-to-batch consistency and reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex preparation steps.

With its exceptional specificity, sensitivity, and versatility, the MIP-1b Polyclonal Antibody is an indispensable tool for researchers and scientists studying the role of MIP-1b protein in various biological processes and diseases. Its reliable performance and ease of use make it an ideal choice for both routine laboratory work and advanced research applications.