MGMT Polyclonal Antibody

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. Methylated-DNA--protein-cysteine methyltransferase encoded by MGMT is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. Methylated-DNA--protein-cysteine methyltransferase catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.

The MGMT Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of the O6-methylguanine-DNA methyltransferase (MGMT) protein. This antibody is produced using a polyclonal approach, ensuring a diverse range of antibodies that recognize different epitopes of the MGMT protein.

The MGMT protein plays a crucial role in DNA repair mechanisms, specifically in the removal of alkyl adducts from the O6 position of guanine residues. Dysregulation or loss of MGMT expression has been associated with increased susceptibility to DNA damage and the development of various cancers.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results.

The MGMT Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy integration into existing laboratory protocols.

With its exceptional performance characteristics and broad application range, the MGMT Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of MGMT in DNA repair mechanisms and its implications in cancer development.