mGluR-4 Polyclonal Antibody

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for GRM4.

The mGluR-4 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of metabotropic glutamate receptor 4 (mGluR-4) in various biological samples. This antibody has been extensively validated and exhibits exceptional sensitivity and specificity, making it an ideal choice for researchers in the field of neuroscience and pharmacology.

The mGluR-4 Polyclonal Antibody is produced using state-of-the-art techniques, ensuring high purity and batch-to-batch consistency. It has been rigorously tested for cross-reactivity with other related receptors to ensure its specificity for mGluR-4. This antibody is suitable for various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its superior performance, the mGluR-4 Polyclonal Antibody enables accurate and reliable detection of mGluR-4 in both cell lines and tissue samples. Its high affinity and sensitivity allow for the detection of low expression levels, facilitating the study of mGluR-4 in various physiological and pathological conditions.

The mGluR-4 Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and saving valuable time in the laboratory. It is provided in a liquid form, allowing for easy and precise dispensing. The antibody is also available in different sizes to accommodate various experimental needs.

In summary, the mGluR-4 Polyclonal Antibody is a reliable and specific tool for the detection and analysis of mGluR-4. Its exceptional performance, high sensitivity, and ease of use make it an indispensable asset for researchers studying the role of mGluR-4 in neurological disorders and drug development.