MEK-3 Polyclonal Antibody

The protein encoded by MAP2K3 (mitogen-activated protein kinase kinase 3) is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for MAP2K3.

The MEK-3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of MEK-3 protein expression in various biological samples. This antibody is produced through a rigorous process of immunization using a recombinant MEK-3 protein, ensuring its high affinity and specificity towards the target protein.

The MEK-3 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its ability to accurately detect endogenous levels of MEK-3 protein in cell lysates, tissue extracts, and other biological matrices.

With its superior sensitivity, this antibody enables researchers to detect even low levels of MEK-3 protein, facilitating the study of its expression patterns and cellular localization. Its robust performance ensures reliable and reproducible results, making it an indispensable tool for both basic research and clinical investigations.

The MEK-3 Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone antibody dilutions. The antibody is also available in various sizes to accommodate different experimental needs.

In summary, the MEK-3 Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of MEK-3 protein expression. Its exceptional sensitivity, robust performance, and convenient formulation make it an ideal choice for researchers in the field of molecular biology, cancer research, and drug discovery.