MEK Kinase-1 Polyclonal Antibody

The protein encoded by MAP3K1 (mitogen-activated protein kinase kinase kinase 1) is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.

The MEK Kinase-1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of MEK Kinase-1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human MEK Kinase-1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The MEK Kinase-1 Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize MEK Kinase-1 protein in human, mouse, and rat tissues. The antibody has also been shown to be highly sensitive, with a detection limit of 0.1 ng of MEK Kinase-1 protein.

This antibody is an essential tool for researchers studying the role of MEK Kinase-1 in various cellular processes, including cell proliferation, differentiation, and apoptosis. It can also be used to investigate the involvement of MEK Kinase-1 in various diseases, including cancer and neurodegenerative disorders.

In summary, the MEK Kinase-1 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of MEK Kinase-1 protein in various biological samples. Its extensive validation and broad range of applications make it an essential tool for researchers studying the role of MEK Kinase-1 in various cellular processes and diseases.