MCT8 Polyclonal Antibody

SLC16A2 (solute carrier family 16 member 2) encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). SLC16A2 is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in SLC16A2 are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. SLC16A2 is subject to X-chromosome inactivation. Mutations in SLC16A2 are the cause of Allan-Herndon-Dudley syndrome.

The MCT8 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of monocarboxylate transporter 8 (MCT8) protein expression in various biological samples. This antibody is produced using advanced immunization techniques and exhibits exceptional affinity and selectivity towards MCT8.

The monocarboxylate transporter 8 (MCT8) is a crucial protein involved in the transport of thyroid hormones across cell membranes. Dysregulation or mutations in the MCT8 gene have been associated with severe neurological and developmental disorders, making it a significant target for research and diagnostic purposes.

The MCT8 Polyclonal Antibody has been rigorously validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It reliably detects endogenous levels of MCT8 protein in a wide range of tissues and cell types, enabling researchers to gain valuable insights into its expression patterns and functional roles.

This antibody is manufactured using high-quality materials and undergoes stringent quality control measures to ensure consistent and reliable performance. It is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage.

With its exceptional specificity and sensitivity, the MCT8 Polyclonal Antibody is an indispensable tool for researchers and clinicians studying the role of MCT8 in thyroid hormone transport and related disorders. Its reliable performance and ease of use make it an ideal choice for a wide range of applications in molecular biology, cell biology, and clinical diagnostics.