MCM4 Polyclonal Antibody

The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

The MCM4 Polyclonal Antibody is a highly specific and sensitive antibody that has been designed to detect the MCM4 protein in various biological samples. This antibody has been extensively validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The MCM4 protein is a member of the minichromosome maintenance (MCM) family of proteins, which are essential for DNA replication and cell division. The MCM4 protein plays a critical role in the initiation of DNA replication and is required for the proper functioning of the replication machinery.

The MCM4 Polyclonal Antibody has been produced using high-quality materials and state-of-the-art techniques to ensure maximum specificity and sensitivity. This antibody has been rigorously tested to ensure that it provides reliable and reproducible results in a variety of experimental conditions.

In summary, the MCM4 Polyclonal Antibody is a valuable tool for researchers studying DNA replication and cell division. Its high specificity and sensitivity make it an ideal choice for a wide range of applications, and its rigorous validation ensures that it provides reliable and reproducible results.