MC1-R Polyclonal Antibody

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that MC1R(MSH) is an important component in determining normal human pigment variation.

The MC1-R Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of melanocortin 1 receptor (MC1-R) protein expression. This antibody is produced using a polyclonal approach, ensuring a diverse range of antibodies that target different epitopes of the MC1-R protein.

The MC1-R Polyclonal Antibody has been rigorously validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional specificity, displaying minimal cross-reactivity with other related proteins. This antibody enables researchers to confidently investigate the expression and localization of MC1-R in various tissues and cell types.

With its high sensitivity, the MC1-R Polyclonal Antibody allows for the detection of low levels of MC1-R protein, making it an ideal choice for studies requiring precise quantification. Its robust performance ensures reliable and reproducible results, facilitating accurate data interpretation.

The MC1-R Polyclonal Antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure consistent performance and batch-to-batch reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation.

In summary, the MC1-R Polyclonal Antibody is a reliable and versatile tool for the investigation of MC1-R protein expression. Its exceptional specificity, sensitivity, and ease of use make it an invaluable asset for researchers in the field of melanocortin receptor biology.