MARK1/2/3/4 Polyclonal Antibody

Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (MARK1-4) of serine/threonine kinases was identified based on their ability to phosphorylate microtubule-associated proteins (MAPs) including tau, MAP2 and MAP4. MARK proteins phosphorylate MAPs within their microtubule binding domains, causing dissociation of MAPs from microtubules and increased microtubule dynamics. In the case of tau, phosphorylation has been hypothesized to contribute to the formation of neurofibrillary tangles observed in Alzheimer's disease. Overexpression of MARK leads to hyperphosphorylation of MAPs, morphological changes and cell death. The tumor suppressor kinase LKB1 phosphorylates MARK and the closely related AMP-kinases within their T-loops, leading to increased activity.

The Mas1-like Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Mas1-like receptors in various biological samples. This antibody is produced through a rigorous process of immunization and purification, ensuring its high affinity and specificity towards the target antigen.

The Mas1-like Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its superior sensitivity allows for the detection of even low abundance Mas1-like receptors, enabling researchers to obtain accurate and reliable results.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency and reproducibility. Its high purity and low background staining contribute to the generation of clear and precise data, facilitating the interpretation and analysis of experimental results.

The Mas1-like Polyclonal Antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming and complex preparation steps. Its long shelf life and stability make it an ideal choice for long-term storage and repeated use, providing researchers with a cost-effective solution for their experimental needs.

In summary, the Mas1-like Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of Mas1-like receptors. Its high specificity, sensitivity, and ease of use make it an invaluable asset for researchers in the fields of molecular biology, pharmacology, and neuroscience.