MAP-4 Polyclonal Antibody

The protein encoded by MAP4 is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.

The MAP-4 Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for use in various research applications. This antibody is produced by immunizing animals with a synthetic peptide corresponding to the C-terminal region of the microtubule-associated protein 4 (MAP-4). The resulting polyclonal antibody is purified using a combination of protein A and protein G chromatography to ensure high purity and specificity.

The MAP-4 Polyclonal Antibody is suitable for use in a variety of applications, including western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for use in detecting MAP-4 in various tissues and cell types, making it an ideal tool for researchers studying microtubule dynamics and cytoskeletal organization.

This antibody is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different research projects. The MAP-4 Polyclonal Antibody is a reliable and high-quality reagent that can help researchers advance their understanding of microtubule-associated proteins and their role in cellular processes.