Lunatic Fringe Polyclonal Antibody

LFNG is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene.

The Lunatic Fringe Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Lunatic Fringe protein expression in various biological samples. This antibody is produced through a rigorous process, ensuring its exceptional quality and performance.

The Lunatic Fringe Polyclonal Antibody exhibits a high affinity towards the Lunatic Fringe protein, enabling accurate and sensitive detection in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its exceptional specificity ensures minimal cross-reactivity with other related proteins, guaranteeing reliable and precise results.

This antibody is manufactured using advanced techniques and state-of-the-art equipment, ensuring batch-to-batch consistency and reproducibility. It has been extensively validated and optimized to provide optimal performance in various experimental conditions, making it an ideal choice for researchers and scientists in the field.

The Lunatic Fringe Polyclonal Antibody is supplied in a convenient and user-friendly format, allowing for easy handling and storage. It is provided in a liquid form, eliminating the need for reconstitution, and is compatible with a variety of commonly used buffers and diluents.

With its exceptional quality, specificity, and reliability, the Lunatic Fringe Polyclonal Antibody is an indispensable tool for studying the Lunatic Fringe protein and its role in various biological processes. It offers researchers a valuable resource to advance their understanding of this protein and its implications in development, disease, and therapeutic interventions.