LOST1 Polyclonal Antibody

TUSC5 (tumor suppressor candidate 5), also known as protein located at seventeen-p-thirteen point three 1, LOST1 or IFITMD3 (interferon-induced transmembrane domain-containing protein D3), is a 177 amino acid multi-pass membrane protein that belongs to the CD225 family. Thought to play a role in fat metabolism, TUSC5 is highly expressed in mammary gland, heart, smooth muscle, skeletal muscle and stomach, with lower levels found in lung and brain. The gene encoding TUSC5 maps to human chromosome 17, which comprises over 2. % of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is liked to predisposition of cancers of the ovary, colon, prostate gland and fallopian tubes.

The LOST1 Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and analysis of LOST1 protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a unique epitope of the LOST1 protein.

The LOST1 Polyclonal Antibody exhibits exceptional affinity and selectivity towards the LOST1 protein, enabling accurate and reliable detection in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its superior sensitivity, this antibody allows for the detection of even low levels of LOST1 protein expression, making it an invaluable tool for researchers studying the role of LOST1 in various cellular processes and disease states.

Furthermore, the LOST1 Polyclonal Antibody has been rigorously validated for its specificity, ensuring minimal cross-reactivity with other proteins, thereby providing precise and accurate results.

The LOST1 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use, and is available in various sizes to accommodate different experimental needs. Each batch of antibody undergoes stringent quality control measures to ensure consistent performance and reliability.

In summary, the LOST1 Polyclonal Antibody is a highly specific, sensitive, and reliable tool for the detection and analysis of LOST1 protein expression, making it an essential component of any research project aiming to elucidate the functional significance of LOST1 in biological systems.