LATS1/2 Polyclonal Antibody

Serine/threonine-protein kinase LATS1/2 encoded by LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene.

The LATS1/2 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of LATS1 and LATS2 proteins. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reproducibility.

LATS1 and LATS2 are key regulators of the Hippo signaling pathway, which plays a critical role in cell proliferation, differentiation, and apoptosis. Dysregulation of this pathway has been implicated in various diseases, including cancer. Therefore, the accurate measurement of LATS1 and LATS2 protein levels is essential for understanding their functional roles and potential therapeutic targets.

The LATS1/2 Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling precise detection of LATS1 and LATS2 proteins in various sample types, including cell lysates and tissue extracts. It has been extensively validated in multiple experimental settings, including Western blotting, immunoprecipitation, and immunofluorescence.

This antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and error-prone antibody dilutions. The LATS1/2 Polyclonal Antibody is compatible with a wide range of secondary detection systems, facilitating seamless integration into existing experimental protocols.

With its superior performance characteristics and robust validation data, the LATS1/2 Polyclonal Antibody is an indispensable tool for researchers studying the Hippo signaling pathway and its implications in various biological processes and diseases. Trust in its reliability and accuracy to advance your scientific investigations and contribute to the understanding of LATS1 and LATS2 protein functions.