Laminin-R Polyclonal Antibody

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. RPSA encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of RPSA exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Introducing the Laminin-R Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of molecular biology. This high-quality antibody is specifically engineered to target and detect Laminin-R, a crucial protein involved in cell adhesion and migration processes.

Crafted with utmost precision and expertise, this polyclonal antibody exhibits exceptional specificity and sensitivity, ensuring accurate and reliable results. Its unique formulation enables it to recognize and bind to Laminin-R with unparalleled affinity, enabling researchers to explore the intricate mechanisms underlying cellular interactions.

The Laminin-R Polyclonal Antibody is meticulously validated through rigorous testing procedures, guaranteeing its superior performance and reproducibility. Its robust design allows for seamless integration into various experimental techniques, including immunohistochemistry, western blotting, and immunofluorescence, empowering researchers to delve deeper into the intricate world of cellular biology.

With its user-friendly application protocol, this antibody offers unparalleled ease of use, making it an ideal choice for both seasoned scientists and novices alike. Its exceptional stability and long shelf life ensure consistent and reliable results, eliminating the need for frequent reordering and minimizing experimental variability.

In summary, the Laminin-R Polyclonal Antibody represents a breakthrough in molecular biology research, providing researchers with an invaluable tool to unravel the complexities of cellular adhesion and migration. With its exceptional specificity, sensitivity, and ease of use, this antibody is poised to revolutionize the field and drive scientific advancements to new heights.