Laminin Beta-1 Polyclonal Antibody

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i. E. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. LAMB1 encodes Laminin subunit beta-1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

The Laminin Beta-1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Laminin Beta-1 protein in various biological samples. This antibody is produced through a rigorous process of immunization and purification, ensuring its high affinity and specificity towards Laminin Beta-1.

Laminin Beta-1 is a crucial component of the extracellular matrix, playing a vital role in cell adhesion, migration, and tissue development. Its aberrant expression has been implicated in various pathological conditions, making it an important target for research and diagnostic purposes.

The Laminin Beta-1 Polyclonal Antibody exhibits exceptional sensitivity and selectivity, enabling accurate and precise detection of Laminin Beta-1 protein in a wide range of sample types, including tissue lysates, cell culture supernatants, and biological fluids. Its versatility allows for diverse applications, such as Western blotting, immunohistochemistry, and ELISA.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, eliminating the need for time-consuming reconstitution.

With its superior performance and reliability, the Laminin Beta-1 Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in studying the role of Laminin Beta-1 in various biological processes and disease mechanisms. Its exceptional quality and performance make it an ideal choice for accurate and reliable detection of Laminin Beta-1 protein in diverse research and diagnostic applications.