Laminin  Alpha-4 Polyclonal Antibody

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i. E. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

The Laminin Alpha-4 Polyclonal Antibody is a highly specific and sensitive antibody that has been designed to detect and quantify the presence of Laminin Alpha-4 in various biological samples. This antibody has been extensively validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Laminin Alpha-4 Polyclonal Antibody is produced using high-quality materials and state-of-the-art techniques to ensure maximum specificity and sensitivity. It has been rigorously tested to ensure that it meets the highest standards of quality and performance.

This antibody is ideal for researchers and scientists who are studying the role of Laminin Alpha-4 in various biological processes, including cell adhesion, migration, and differentiation. It is also useful for those who are investigating the potential therapeutic applications of Laminin Alpha-4 in various diseases and disorders.

Overall, the Laminin Alpha-4 Polyclonal Antibody is a valuable tool for researchers and scientists who are working in the fields of cell biology, molecular biology, and biochemistry. Its high specificity and sensitivity make it an essential component of any research project that involves the detection and quantification of Laminin Alpha-4.