Lamin B1 Polyclonal Antibody

LMNB1 encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of LMNB1 is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants.

The Lamin B1 Polyclonal Antibody is a highly specific and sensitive antibody that is designed to detect Lamin B1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Lamin B1 protein. The Lamin B1 Polyclonal Antibody is purified using protein A affinity chromatography and is validated for use in Western blotting, immunohistochemistry, and immunofluorescence applications.

The Lamin B1 Polyclonal Antibody is a valuable tool for researchers studying the structure and function of the nuclear envelope and its associated proteins. Lamin B1 is a major component of the nuclear lamina, a network of intermediate filaments that provides structural support to the nucleus and regulates gene expression. Abnormalities in Lamin B1 expression or localization have been linked to a variety of human diseases, including muscular dystrophy, progeria, and cancer.

The Lamin B1 Polyclonal Antibody is highly specific for Lamin B1 and does not cross-react with other lamin isoforms or related proteins. It has been extensively tested in a variety of cell types and tissues, including human, mouse, and rat samples. The antibody is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

Overall, the Lamin B1 Polyclonal Antibody is a reliable and versatile tool for researchers studying the nuclear envelope and its associated proteins. Its high specificity and sensitivity make it an ideal choice for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.